Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals from your microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactions, that h... https://elizabethl420gpy7.wikipowell.com/user