Epidural clonidine applied as an adjunct to area anesthetics has a few distinct mechanisms of action. 1st, the stimulation of alpha-2-receptors within the dorsal horn decreases pain transmission. Next, clonidine might cause regional vasoconstriction that limits vascular removal of local epidural anesthetics. Clonidine is dispersed in breast milk; warning https://www.proleviate.com/post/the-new-pain-killer-conolidine