There's a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to decrease afferent pain transmission and produce analgesia. As a result, medicines like clonidine that concentrate on alpha-two receptors can affect the transmission of soreness. This doc doesn't comprise https://bookmarkpagerank.com/story19776136/the-ultimate-guide-to-onolidine